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          • Proteins & Peptides ›
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          Connexin 43 Proteins

          Connexin 43 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed?... Connexin 43 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us... Connexin 43 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... Connexin 43 Human recombinant proteins are validated for use in the following applications: Blocking Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Browse all 2 proteins. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

          Protein Information

          Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.

          Synonyms

          alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; Cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3

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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          Invitrogen
          Human Connexin 43 (aa 307-376) Control Fragment Recombinant Protein
          Invitrogen
          Human Connexin 43 (aa 307-376) Control Fragment Recombinant Protein
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          Human
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          E. coli
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          Ctrl BLOCK
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          Cat # RP-102649

          100 µL

          Invitrogen
          Human Connexin 43 (aa 242-306) Control Fragment Recombinant Protein
          Invitrogen
          Human Connexin 43 (aa 242-306) Control Fragment Recombinant Protein
          Host
          Species
          Human
          Expression System
          E. coli
          Product Grade
          Research Use Only
          Application
          Ctrl BLOCK
          Price
          Special offer
          Online exclusive
          Online offer:
          Cat # RP-108378

          100 µL

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